Table 3 The top 10 major bacterial composition of small intestine at genus level. (%).

From: Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii

 

vehicle

rabeprazole

vonoprazan

5 mg/kg

20 mg/kg

5 mg/kg

20 mg/kg

Lactobacillus

37.56 ± 5.66

46.71 ± 7.74

33.77 ± 2.59

45.45 ± 7.56

35.46 ± 7.92

Clostridium

4.12 ± 1.12

5.34 ± 1.72

9.73 ± 1.45*

1.91 ± 0.49

7.94 ± 0.89*

Akkermansia

0.30 ± 0.06

1.76 ± 0.62*

1.60 ± 0.26*

1.21 ± 0.53

1.22 ± 0.56

Eubacterium

0.46 ± 0.28

0.42 ± 0.11

0.43 ± 0.09

0.17 ± 0.05

0.43 ± 0.06

Roseburia

0.02 ± 0.01

0.19 ± 0.06

0.31 ± 0.09*

0.17 ± 0.12

0.23 ± 0.08

Candidatus Arthromitus

2.94 ± 0.89

0.89 ± 0.60

0.33 ± 0.16*

2.34 ± 1.48

0.50 ± 0.33

Ruminococcus

0.03 ± 0.02

0.18 ± 0.11

1.10 ± 0.27**

0.15 ± 0.09

0.31 ± 0.15

Oscillospira

0.01 ± 0.01

0.38 ± 0.17*

0.53 ± 0.09*

0.03 ± 0.02

0.53 ± 0.17*

Parabacteroides

0.01 ± 0.01

0.13 ± 0.06

0.42 ± 0.08*

0.09 ± 0.07

0.35 ± 0.07*

Escherichia

0.23 ± 0.13

0.05 ± 0.03

0.00 ± 0.00

0.97 ± 0.44

2.51 ± 2.49

  1. Identity ≥94% Mean ± s.e. *p < 0.05 vs Vehicle, **p < 0.01 vs Vehicle.
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