Table 4 The top 20 major bacterial composition of small intestine at species level. (%).

From: Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii

  

vehicle

rabeprazole

vonoprazan

% id

 

5 mg/kg

20 mg/kg

5 mg/kg

20 mg/kg 

total_OTU00007

Lactobacillus johnsonii

100.0

18.20 ± 4.24

12.26 ± 2.00

8.43 ± 1.21*

12.77 ± 3.45

10.03 ± 2.40+

total_OTU00029

Barnesiella intestinihominis

86.5

13.34 ± 3.10

11.34 ± 2.08

11.33 ± 1.29

9.63 ± 2.19

13.90 ± 1.29

total_OTU00016

Lactobacillus intestinalis

100.0

5.59 ± 1.00

11.54 ± 2.31*

11.40 ± 0.82*

17.61 ± 3.01**

8.11 ± 1.60

total_OTU00013

Lactobacillus reuteri

100.0

8.63 ± 1.29

11.95 ± 2.79

6.98 ± 0.66

8.26 ± 1.64

7.75 ± 1.96

total_OTU00041

Barnesiella intestinihominis

88.6

7.69 ± 1.94

5.90 ± 0.95

6.75 ± 0.66

6.73 ± 1.57

5.63 ± 0.85

total_OTU00024

Lactobacillus murinus

100.0

3.11 ± 1.04

8.44 ± 1.32*

4.41 ± 0.52

5.06 ± 1.42

7.80 ± 2.93*

total_OTU00096

Barnesiella intestinihominis

86.9

4.05 ± 0.70

3.63 ± 0.70

3.96 ± 0.31

4.75 ± 0.73

5.09 ± 0.73

total_OTU00129

Porphyromonas HF001

86.0

3.49 ± 0.68

3.28 ± 0.61

2.53 ± 0.34

2.68 ± 0.63

3.48 ± 0.52

total_OTU00116

Porphyromonas catoniae

88.1

2.37 ± 0.48

1.99 ± 0.46

3.03 ± 0.29

3.63 ± 0.91

3.28 ± 0.60

total_OTU00097

Porphyromonas catoniae

86.0

2.40 ± 0.46

2.20 ± 0.37

1.86 ± 0.17

3.28 ± 0.82

2.42 ± 0.56

total_OTU00188

Barnesiella intestinihominis

87.2

1.40 ± 0.34

1.65 ± 0.29

2.20 ± 0.22

1.68 ± 0.44

1.74 ± 0.43

total_OTU00546

Porphyromonas catoniae

86.9

3.54 ± 0.69

0.86 ± 0.16**

1.13 ± 0.09**

1.98 ± 0.47**

1.04 ± 0.24**

total_OTU00540

Porphyromonas catoniae ATCC 51270

85.0

1.62 ± 0.31

1.46 ± 0.37

1.49 ± 0.15

1.72 ± 0.43

1.90 ± 0.50

total_OTU00017

Candidatus Arthromitus sp. SFB-mouse

100.0

2.86 ± 0.86

0.86 ± 0.59

0.31 ± 0.15*

2.33 ± 1.48

0.49 ± 0.32

total_OTU00208

Akkermansia muciniphila

100.0

0.30 ± 0.06

1.74 ± 0.61*

1.56 ± 0.26

1.18 ± 0.52

1.21 ± 0.56

total_OTU00207

Bacteroides sp. Tilapia9

84.1

1.04 ± 0.20

1.04 ± 0.30

1.17 ± 0.14

1.04 ± 0.25

1.08 ± 0.27

total_OTU00127

Clostridium disporicum

99.5

1.75 ± 0.46

0.06 ± 0.03*

0.01 ± 0.01*

0.81 ± 0.27

2.21 ± 1.12

total_OTU00276

Eubacterium biforme DSM 3989

87.3

0.71 ± 0.19

0.72 ± 0.16

2.36 ± 0.26**

0.00 ± 0.00**

0.07 ± 0.02*

total_OTU00399

Escherichia coli

100.0

0.23 ± 0.13

0.05 ± 0.03

0.00 ± 0.00

0.94 ± 0.42

2.49 ± 2.47

total_OTU00143

[Bacillus] sp. KITNT-3

100.0

1.79 ± 1.20

0.05 ± 0.03*

0.00 ± 0.00*

0.84 ± 0.48

0.11 ± 0.07

  1. Mean ± s.e. *p < 0.05 vs Vehicle, **p < 0.01 vs Vehicle, + P = 0.059.