Figure 3 | Scientific Reports

Figure 3

From: Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome

Figure 3

C57BL/6 mice undergoing splenic irradiation with a multi-fraction regimen of 1 Gy per day for 5 days or a single fraction of 5 Gy experience severe lymphopenia irrespective of dose rate. (a–d) Flow cytometric CD3, CD4, CD8, and CD19 counts in the peripheral blood of mice on day 3 following conventional or ultra-high dose rate RT with the multi-fraction regimen. (e–h) Flow cytometric CD3, CD4, CD8, and CD19 counts in the peripheral blood of mice on day 3 following conventional or ultra-high dose rate RT with a single fraction of 5 Gy. Data are the mean percentages of cells ± SE. *p < 0.05 compared between control and other cohorts. Data are derived from experiment conducted in triplicates. (n = 5 in control, high dose rate and conventional dose rate group).

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