Figure 1 | Scientific Reports

Figure 1

From: Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway

Figure 1

TFG expression in tumor tissues of CCA patients. (A) The reactivity of TFG in tumor tissues of CCA and hepatoma was determined using UEA-I histochemistry. (a) Normal bile ducts showed negative TFG signals, whereas (b) hyperplastic/dysplastic bile ducts, (c) papillary type- and (d) non-papillary type CCA showed positive TFG expressions. (e) Hepatoma did not express TFG. Original magnification; a–c x200 and d,e x400. Scale bar = 100 μm for (a–c), and = 50 μm for (d,e). (B) Differential expressions of TFG found in normal bile duct (NBD), hyperplastic/dysplastic bile ducts (HP/DP), CCA and hepatoma (HCC). Data are presented as a percentage of total cases. (C) The expression levels of TFG (mean ± S.D.) in HP/DP bile ducts and CCA tissues were significantly elevated compared with those of normal bile ducts. ***P < 0.001; Student’s t-test. (D) Kaplan-Meier analysis and Log-rank tests showing a significant correlation of CCA patients with high TFG and short survival (P = 0.024).

Back to article page