Figure 2 | Scientific Reports

Figure 2

From: Terminal fucose mediates progression of human cholangiocarcinoma through EGF/EGFR activation and the Akt/Erk signaling pathway

Figure 2

The expression profile of TFG in liver sections of hamsters. (A) Hamsters were divided into 4 groups of the Ov-associated CCA hamster model: untreated control, Ov infected, NDMA treated and Ov + NDMA (CCA). Liver sections were obtained from each group at 1, 3 and 6-month post-treatment. The reactivity of TFG in tissues was determined using UEA-I histochemistry. TFG signals were undetectable in normal bile ducts but were observed in every treatment group and as early as 1-month post-treatment. Original magnification; x 200. Scale bar = 100 μm. (B) The TFG signal was quantitated according to the Allred scoring system. TFG scores were analyzed according to the pathology of the bile duct epithelia as normal (NBD), hyperplastic/dysplastic bile ducts (HP/DP), and CCA observed at each time point. Data are mean ± S.D. Numbers indicate the number of animals that had positive TFG/total numbers. *P < 0.05 and ***P < 0.001; Student’s t-test.

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