Figure 1 | Scientific Reports

Figure 1

From: Mitochondrial Dysfunction and Changes in High-Energy Compounds in Different Cellular Models Associated to Hypoxia: Implication to Schizophrenia

Figure 1

Cellular viability reduction in Wistar (A,C) and SHR (B,D) astrocytes after exposure to chemical and gaseous hypoxia. Cells were exposed to CoCl2 (800 µM, 1 mM, 2 mM and 5 mM for 24 hrs) and gaseous hypoxia (8, 18 and 24 hrs) and it was performed MTT test. Data is represented by mean ± SD, and it was normalized as percentage of control group (N = 4, in duplicates). Statistical analysis was performed using One-Way ANOVA followed by post-hoc Duncan. It was considered significant p < 0.05; ***p < 0.0001 and ****p < 0.00001, in relation to Wistar (both without treatment and normoxia group); @@@@p < 0.00001, in relation to Wistar cells exposed to both CoCl2 800 µM and 8 hrs of hypoxia; ###p < 0.0001 and ####p < 0.00001, in relation to SHR (both without treatment and normoxia group); &&&&p < 0.00001, in relation to SHR cells exposed to CoCl2 800 µM and 1 mM, and 8 hrs of hypoxia.

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