Figure 5

Transplantation of QN thymocytes from non-leukemic NP23-NHD13 thymic cells leads to AML. (a) Purification of QN thymocytes from non-leukemic thymus and transplantation of 100 cells per recipient. (b) Survival curve of WT and NP23-NHD13 QN recipients, n = 4–5 mice per group. Data are analyzed by Log-rank (Mantel-Cox) test. c Engraftment of Ly45.2⁺/Mac1⁺ cells at indicated time interval (dotted circle indicates engraftment data obtained from BM). (d) Flow cytometry profile of representative transplant recipient (R-1) indicates engraftment and differentiation of QN thymocytes in both BM and thymus. ^**P < 0.01.