Figure 3
Conserved histone markers of the naive and primed state in human and mouse. (a) Relative abundance (RA) fold changes between primed (P0) and naive (P12) hESCs. Asterisks indicate significance (N = 4, p < 0.05). (b) Scatter plot of the log2 fold changes of the RA of hPTMs between the naive and primed state, which were identified in both hESCs and mESCs. Significant changes in mouse are indicated by a right hemisphere, while the left hemisphere indicates significance in human. Dx: Day x of the experiment. mESC were converted from naive to primed and hESCs from primed to naive. Histone H31 and H33 as well as K36 and K37 were merged for this comparison. H4K8Cr and H4/K5Me were identified together on the same peptide backbone and thus have identical RA values, in both mouse and human.
