Table 2 Coagulation profile of PEVs assessed by Thromboelastography.

From: Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

Group

Plasma

Whole Blood

α-angle (degrees)

MA (mm)

α-angle (degrees)

MA (mm)

PEVs, n = 4

81.6 ± 0.4

36.6 ± 0.5

80.6 ± 0.4

69.9 ± 0.9

Vehicle, n = 4

80.9 ± 0.5

31.6 ± 1

78.8 ± 0.3

65.6 ± 0.9

p value

0.26

0.01*

0.02*

0.02*

  1. PEVs isolation from 4 different donors were exposed to rat fresh frozen plasma. PBS was used as negative control. Difference between mean values were analyzed by student t test, *p < 0.05 vs. Vehicle. Data reported as mean ± SEM. MA = maximum amplitude, PEVs = Platelet-derived extracellular vesicles.
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