Table 3 Comparisons among groups at baseline and assessment of injury severity.

From: Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

 

Vehicle, n = 16

FPLT, n = 8

PEVs, n = 8

ANOVA

Mean

SEM

Mean

SEM

Mean

SEM

p value

(A) Baseline values

Body weight (g)

338±

5

351±

8

334±

3

0.17

Blood volume (mL)

22±

0.3

23±

0.5

22±

0.2

0.17

MAP (mmHg)

104±

1

103±

1

101±

2

0.33

Hematocrit (%)

42.7±

0.8

44.5±

1.4

44.6±

1.4

0.33

Plasma protein(g/dL)

4.6±

0.1

5.3±

0.3

4.7±

0.2

0.09

Lactate (mmol/L)

0.6±

0.0

0.6±

0.1

0.6±

0.1

0.96

BE (mmol/L)

5.3±

0.7

2.7±

1.0

6.3±

0.8

0.08

CO2 (mmHg)

47±

3

46±

3

44±

1

0.10

O2 (mmHg)

509±

28

474±

38

499±

33

0.80

pH

7.4±

0.0

7.4±

0.0

7.4±

0.0

0.18

(B) Injury Severity parameters

Excised Liver (g)

1.2±

0.1

1.1±

0.0

1.1±

0.1

0.31

Bleeding Surface (cm2)

1.9±

0.1

1.7±

0.1

1.9±

0.1

0.12

MAP-1 min (mmHg)

51±

6

52±

6

63±

6.4

0.39

  1. (A) BW, hemodynamics and blood gasses were comparable in all groups. (B) The weight, bleeding surface and MAP one minute after liver excision demonstrates a comparable injury among the groups. Data reported as mean ± SEM and compared by 1-way ANOVA.