Figure 7 | Scientific Reports

Figure 7

From: New bioresorbable wraps based on oxidized polyvinyl alcohol and leukocyte-fibrin-platelet membrane to support peripheral nerve neurorrhaphy: preclinical comparison versus NeuraWrap

Figure 7The alternative text for this image may have been generated using AI.

Experimental design and explants sampling for histological and immunohistochemical characterization and morphometric analysis by Transmission Electron Microscope. The image represents the surgical procedure, including sharp transection (a), coaptation by end-to-end neurorrhaphy (b) and wrap implantation (c). After 12 weeks, sciatic nerves sectioning occurred before histological and immunohistochemical analysis, Transmission Electron Microscopy and Second Harmonic Generation (SHG) studies. In (d), the investigated areas are showed in correspondence to the red-dotted lines. The coaptation site (C) was analyzed by both histology (haematoxylin and eosin) and immunohistochemistry (anti-CD3, anti-F4/80, anti-S100, anti-β-tubulin). The portions next to the coaptation site (A and B, from the nearest area to the most distant area, respectively) were analyzed by Toluidine-Blue staining and TEM. All portions were visualized by SHG.

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