Figure 4 | Scientific Reports

Figure 4

From: Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model

Figure 4

Represents the in vivo performance study of gliclazide loaded PLGA SGNCs formulation, (a) Pharmacodynamic responses of pure gliclazide, placebo and optimized formulation, SGNCF1 on type II diabetic rats; (b) Plasma mean gliclazide concentration–time curves after single oral dosing of pure gliclazide and optimized formulation, SGNCF1 on type 2diabetic rats; (c) Represents Pharmacokinetic-Pharmacodynamic correlation plot of gliclazide loaded PLGA SGNCs formulation on type 2 diabetic rats. Each point represents the mean ± SD of the data obtained from the experiments (n = 6).

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