Table 5 Different batches of formulations and their composition used in gliclazide loaded PLGA second-generation nanocrystals preparation using Taguchi L type orthogonal array design.
Formulation code | Gliclazide: PLGA ratio | Stabilizer type | Percentage of Stabilizer (%w/v) | Homogenization cycles at 1000 bar |
|---|---|---|---|---|
SGNCF1 | 1:0.5 | Poloxamer 188 | 0.5 | 5 |
SGNCF2 | 1:0.5 | PEG 4000 | 0.75 | 10 |
SGNCF3 | 1:0.5 | HPMC(E15) | 1.0 | 20 |
SGNCF4 | 1:0.75 | Poloxamer 188 | 0.75 | 20 |
SGNCF5 | 1:0.75 | PEG 4000 | 1.0 | 5 |
SGNCF6 | 1:0.75 | HPMC(E15) | 0.5 | 10 |
SGNCF7 | 1:1 | Poloxamer 188 | 1.0 | 10 |
SGNCF8 | 1:1 | PEG 4000 | 0.5 | 20 |
SGNCF9 | 1:1 | HPMC (E15) | 0.75 | 5 |
