Table 2 Top GO biological processes enriched in each replicated module. The associated effect is shown in brackets.
From: Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking
ID | GO biological process | FDR |
|---|---|---|
module 22 (smoking) | ||
GO:0031333 | negative regulation of protein complex assembly | 1.77 × 10−02 |
module 11 (smoking) | ||
GO:1901661 | quinone metabolic process | 6.30 × 10−06 |
GO:0006081 | cellular aldehyde metabolic process | 6.30 × 10−06 |
GO:0019748 | secondary metabolic process | 1.86 × 10−05 |
GO:0098869 | cellular oxidant detoxification | 2.05 × 10−05 |
GO:0034754 | cellular hormone metabolic process | 4.09 × 10−05 |
module 17 (smoking) | ||
No significant enrichment. | ||
module 15 (smoking) | ||
GO:0070268 | cornification | 4.60 × 10−02 |
GO:0006486 | protein glycosylation | 4.60 × 10−02 |
GO:0043413 | macromolecule glycosylation | 4.60 × 10−02 |
GO:0016266 | O-glycan processing | 4.60 × 10−02 |
GO:0046718 | viral entry into host cell | 4.60 × 10−02 |
module 36 (sex and smoking:sex) | ||
GO:0006413 | translational initiation | 1.12 × 10−03 |
GO:0006687 | glycosphingolipid metabolic process | 4.80 × 10−02 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 4.80 × 10−02 |
GO:0006613 | cotranslational protein targeting to membrane | 4.80 × 10−02 |
GO:0045047 | protein targeting to ER | 4.80 × 10−02 |
module 02 (smoking:sex) | ||
GO:0006914 | autophagy | 2.91 × 10−06 |
GO:0061919 | process utilizing autophagic mechanism | 2.91 × 10−06 |
GO:0000422 | autophagy of mitochondrion | 9.42 × 10−05 |
GO:0061726 | mitochondrion disassembly | 9.42 × 10−05 |
GO:0035966 | response to topologically incorrect protein | 4.82 × 10−04 |
module 34 (smoking:sex) | ||
GO:0009615 | response to virus | 1.29 × 10−14 |
GO:0045071 | negative regulation of viral genome replication | 2.53 × 10−07 |
GO:0043900 | regulation of multi-organism process | 3.25 × 10−07 |
GO:0019079 | viral genome replication | 6.30 × 10−06 |
GO:0060337 | type I interferon signaling pathway | 2.52 × 10−03 |
