Figure 1

Differential expression of H. contortus miRNAs from microarray data. Rooted dendogram of complete linkage hierarchical clustering of miRNAs showing differential expression between at least one developmental stage or in adult female gut tissue, identified by ANOVA. Corrected normalised data with microarray threshold signal of >500 fluorescent units and p-value < 0.05. Groups are labeled according to life-cycle stage or gut tissue showing the highest level of expression. Data are displayed using a heat-map and miRNA names are color-coded according to conservation status, as indicated. Note that hco-mir-5885a/b/c-3p, enriched in L4 stage, is homologous to cel-mir-58 and Drosophila bantam.