Table 1 High confidence predicted target genes of cel-mir-228 and cel-mir-235 using PITA and TargetScan.
C. elegans gene | Cosmid ID | Known/proposed function (Wormbase) |
|---|---|---|
miRNA: cel-mir-228 | ||
mboa-2 sterol O-acyltransferase | H19N07.4 | Lipid metabolism |
transketolase | Y39E4A.3 | Mitochondrial enzyme; branched chain keto dehydrogenase (BCKD) component; lifespan |
syg-1 cell adhesion molecule | K02E10.8 | Synapse formation |
sek-1 map kinase kinase | R03G5.2 | Innate immune response |
glucosidase | T04A8.7 | Development; apoptosis |
inx-1 innexin | C16E9.4 | Thermotaxis; defecation |
dbt-1 transacylase | ZK669.4 | Larval and embryonic development; BCKD component |
skpo-1 peroxidase | F49E12.1 | Morphogenesis; innate immunity |
tim-1 timeless | Y75B8A.22 | Regulation of developmental timing |
sulfotransferase | C18B2.2 | unknown |
ckr-2 neuropeptide receptor | Y39A3B.5 | Digestive enzyme secretion; lipid storage; lifespan |
eps-8 cell signaling adaptor | Y57G11C.24 | Intestinal morphology |
N/A | T26C5.2 | unknown |
miRNA: cel-mir-235 | ||
rbc-1 (RaBConnectin related) | F54E4.1 | Re-association of vacuolar ATPase after glucose starvation |
N/A | F33D4.6 | Lipid storage; larval development; morphogenesis |
zmp-2 zinc metalloprotease | H19M22.3 | Molting; larval development; disease resistance |
atf-2 cAMP-dependent | K08F8.2 transcription factor | Excretory cell development; negative regulator of autophagy and apoptosis |
ets-4 transcription factor | F22A3.1 | Lipid catabolism; lifespan |
