Figure 5

Predicted intermolecular interactions between FAM E3 and the RNA binding site of ZIKV NS3^Hel. 3D structure of the RNA binding site of ZIKV NS3^Hel docked with FAM E3, highlighting the main interactions between FAM E3 and amino acid residues, through hydrogen bonds (dotted black lines) and hydrophobic interactions (transparent green surface) (a). 2D representation of the protein-ligand interactions (b).