Figure 2 | Scientific Reports

Figure 2

From: Calorie restriction slows age-related microbiota changes in an Alzheimer’s disease model in female mice

Figure 2

The effect of CR on the aging microbiota in WT and Tg2576 mice. (a) Composition of the fecal microbiota from study day 0 (~3 MO) until study day 369 (~15 MO). Mice were individually housed throughout the experiment, eliminating cage effects. (b) Age-related microbiota drift. Divergence from microbiota at study day 59 was measured using unweighted UniFrac distances on a per-mouse basis; slopes were calculated and tested by linear regression whether significantly non-zero. *p < 0.05. (c–f) Microbial taxa that are increased in 5 MO or 15 MO female mice, LEfSe p < 0.05. Each cladogram represents all taxa detected at >0.1%, shown at the Kingdom phylogenetic level through the genus level. A yellow circle depicts taxa present, but not enriched. Red circles are enriched in aging, and green enriched in young animals. The size of the circle corresponds to the population of each taxon.

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