Table 2 The association between type of vascular access and all-cause mortality risk at different level of sCCI.

From: The Impact of Comorbidity Burden on The Association between Vascular Access Type and Clinical Outcomes among Elderly Patients Undergoing Hemodialysis

 

Model 1

Model 2

Model 3

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Lowest tertile of sCCI (4–5)

AVF (n = 6,748)

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

AVG (n = 1,515)

1.29 (1.12–1.48)

<0.001

1.24 (1.08–1.42)

0.002

1.04 (0.67–1.63)

0.86

CVC (n = 1,528)

4.05 (3.54–4.63)

<0.001

2.45 (2.14–2.81)

<0.001

2.81 (1.90–4.16)

<0.001

Middle tertile of sCCI (6)

AVF (n = 5,041)

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

AVG (n = 1,423)

1.29 (1.12–1.47)

<0.001

1.27 (1.11–1.24)

0.001

1.20 (0.88–1.65)

0.25

CVC (n = 1,685)

3.38 (3.00–3.82)

<0.001

2.30 (2.03–2.60)

<0.001

2.54 (1.83–3.53)

<0.001

Highest tertile of sCCI (≥7)

AVF (n = 3,058)

1.00 (reference)

 

1.00 (reference)

 

1.00 (reference)

 

AVG (n = 968)

1.39 (1.21–1.60)

<0.001

1.27 (1.10–1.26)

0.001

1.33 (1.00–1.75)

0.04

CVC (n = 1,134)

3.22 (2.81–3.69)

<0.001

2.01 (1.75–2.30)

<0.001

1.43 (1.08–1.90)

0.01

  1. Model 1: Unadjusted.
  2. Model 2: Adjusted for age and sex.
  3. Model 3: Model 2 + dialysis vintage, BMI, predialysis SBP, etiology of ESRD, functional status, history of hypertension, diabetes, or CVDs, hemoglobin, serum albumin, and HbA1c.
  4. Abbreviation: sCCI, simplified Charlson comorbidity index; HR, hazard ratio; CI, confidence interval; AVF, arteriovenous fistula; AVG, arteriovenous graft; CVC, central venous catheter; BMI, body mass index; SBP, systolic blood pressure; ESRD, end-stage renal disease; CVD, cardiovascular disease.
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