Figure 2
Pathological changes and analysis of colon tissue. (A) Normal control group; (B): model group (100× magnification); (C): ***P = 0.001; data are presented as the \(\overline{{\rm{x}}}\) ± SD. In the model group, inflammatory cells infiltrated the muscularis and muscle layers of the mucosa and the glandular edema in the epithelium. DAI score. (D) During the modeling period, weight changes, fecal morphology, blood in the stool, and survival rate were measured every day, and the DAI was calculated. P = 0.012, the model group compared to the control group. Pathological changes in colon tissue. (E) Normal control group; (F): model group. In the model group, inflammatory cells infiltrated the whole layer of the intestinal wall, considerable cellulose exudation and cell proliferation in the intestinal wall caused swelling of the intestinal wall, and the intestinal lumen was narrow (100× magnification). In severe cases, the epithelial structure disappeared, and the organizational structure was unclear. Score. (G) Colon histopathology score. (H) Mouse DAI score. Changes in mouse body weight. (I) Changes in mouse body weight of the normal, model, IV, and IP groups. (J) Changes in mouse body weight in the normal, model, hUCMSC, and mUCMSC groups.
