Figure 6
From: A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema
Lymphatic injury results in characteristic subcutaneous tissue expansion, collagen deposition, and T-cell infiltration as seen in human lymphedema. (A) Representative H&E stained cross-section of rat neck skin from the lymphadenectomy group. Horizontal scale bars represent 100 μm. (B) Representative H&E stained cross-section of rat neck skin from the sham group. Note the increase in dermal and subcutis thickness in lymphadenectomy animals compared to sham animals. (C) Representative picrosirius red stained cross-section of rat neck skin from the lymphadenectomy group. Horizontal scale bars represent 100 μm. (D) Representative picrosirius red stained cross-section of rat neck skin from the sham group. Note the increase in collagen deposition in lymphadenectomy animals compared to sham animals. (E) Representative CD3 stained cross-section of rat neck skin from the lymphadenectomy group. Horizontal scale bars represent 100 μm, CD3+ T-lymphocytes can be appreciated in brown. (F) Representative CD3 stained cross-section of rat neck skin from the sham group. Note the increase in CD3+ lymphocytic infiltration in lymphadenectomy animals compared to sham animals.
