Figure 2 | Scientific Reports

Figure 2

From: Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study

Figure 2

Transcriptional profiles of healthy household contacts and endemic controls. Gene expression levels of 103 target genes were assessed by dual-color RT-MLPA performed on ex vivo RNA isolated from whole blood of healthy household contacts (HHC; n = 83; black circles) and endemic controls (EC; n = 200; grey circles) from Bangladesh, Brazil, Ethiopia and Nepal. Log2-transformations of peak areas (normalized to GAPDH) of genes significantly differentially expressed between HHC and EC are shown on the y-axis. Raw p-values were calculated using the Mann–Whitney test and adjusted for multiple comparisons using the Benjamini-Hochberg correction40. *adjusted p-values < 0.05; **adjusted p-values < 0.01; (see Table S6).

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