Figure 6
CLEN but not DEX treatment exacerbated ozone-induced lung protein leakage, cytokine changes and neutrophilic inflammation (study 1). BALF protein (A), albumin (B), NAG activity (C), IL-6 (D), TNF-α (E), macrophage numbers (F), and neutrophil numbers (G) were assessed in rats after the second day of air or ozone (0.8 ppm) exposure (4 hr/day for 2 consecutive days). Bar graphs show mean ± SEM of n = 6–8 animals/group. Significant differences between groups (p value ≤ 0.05) are indicated by * for ozone effect when compared to corresponding air-exposed rats, † for drug effect when compared to corresponding vehicle (SAL; saline)-treated rats, and ‡ for drug dose effect for the same exposure.
