Figure 7 | Scientific Reports

Figure 7

From: Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor

Figure 7

Trial 1 Histology (Day 0 Treatment). Coronal brain sections (top row, 2.5×) demonstrate presence of gross tumor (*) in (a) Untreated Control (CTR) rat, and polymer remnants (ϕ) with no evidence of residual bulk tumor in rats treated with (b) UC-1 and (c) UC-2 NanoMeshes. High magnification (20×) images (bottom row) demonstrate hypercellular tumor with some infiltration at the margin of (d) control brain, and few reactive cells (arrow) in (e) UC-1- and (f) UC-2-treated brains. Control rats died spontaneously on day 10 from 9L gliosarcoma, while treated animals were healthy long-term survivors sacrificed at day 150 for histological analysis.

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