Figure 8 | Scientific Reports

Figure 8

From: Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

Figure 8

Summary of pathways involved in cisplatin and curcumin-induced TRPM2 channel activation and tumor cell death through excessive reactive oxygen species (ROS). Cisplatin can lead in Hep2. Nudix box domain of TRPM2 channel is sensitive to ROS. ROS-induced TRPM2 activation stimulates excessive Ca2+ influx. ROS are produced in the mitochondria through the influx of excessive Ca2+. The main mechanism in the cell death effect of curcumin is mediated by stimulation of ROS-mediated caspase -3 and -9 activations. In response, cisplatin and curcumin in the Hep2 cells initiates a pro-oxidant response that stimulates the ROS and lipid peroxidation (MDA) into less harmful products by inhibiting reduced glutathione (RGS) and glutathione peroxidase (GSPx).

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