Table 1 Identified potential biomarkers of cecal samples between the control and RSB treatment groups.
Metabolites | RT(min) | m/z | VIP | Formula | Trend | Related pathway |
|---|---|---|---|---|---|---|
L-Phenylalanine | 3.56 | 148 | 1.90 | C9H11NO2 | ↑** | Phenylalanine metabolism |
L-Glutamate | 4.30 | 130 | 1.24 | C5H9NO4 | ↑** | Arginine biosynthesis |
L-Isoleucine | 0.80 | 132 | 2.37 | C6H13NO2 | ↓* | Valine, leucine and isoleucine metabolism |
3-Phenylpropanoic acid | 6.87 | 151 | 1.88 | C9H10O2 | ↑** | Phenylalanine metabolism |
Benzoic acid | 6.44 | 123 | 1.57 | C7H6O2 | ↓** | Phenylalanine metabolism |
Chenodeoxycholic acid | 8.27 | 415 | 1.64 | C24H40O4 | ↑** | Primary bile acid biosynthesis |
Indole-3-acetic acid | 4.75 | 176 | 1.02 | C10H9NO2 | ↓** | Tryptophan metabolism |
Tetradecanoic acid | 4.25 | 267 | 2.30 | C14H28O2 | ↓** | Fatty acid biosynthesis |
Cholic acid | 8.15 | 391 | 1.53 | C24H40O5 | ↑** | Primary bile acid biosynthesis |
7-Dehydrocholesterol | 9.70 | 385 | 1.97 | C27H44O | ↑** | Steroid biosynthesis |
(5Z, 8Z, 11Z, 14Z, 17Z)-Eicosapentaenoic acid | 7.45 | 307 | 1.92 | C20H34O2 | ↑** | Biosynthesis of unsaturated fatty acids |
11-Deoxycorticosterone | 6.08 | 331 | 2.80 | C21H30O3 | ↑** | Steroid hormone biosynthesis |
Retinol | 7.95 | 287 | 1.56 | C20H30O | ↑** | Retinol metabolism |