Figure 3
From: Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy
Predictions for patient 7 at each round of time series cross-validation with the four week prediction horizon for the models TCM (top) and JM (bottom). The plot for JM lacks predictions for treatment days 275–350, since the differential equation solver could not solve JM conditional on the parameter estimates found during optimisation. The 6 MP dosage for the depicted patient was intensified incrementally to 62.5 mg during the treatment. The dosage was not intensified further due to low neutrophil counts.
