Table 3 The biological function of the main up- and down-regulated proteins in the WD group compared to their controls identified by proteomics.
From: Landscape of heart proteome changes in a diet-induced obesity model
BIOLOGICAL FUNCTION | PROTEINS | |
|---|---|---|
Up | Down | |
Lipid metabolism | ||
Receptor and transport of fatty acids | CD36; FABP3; FABP4 | — |
Mitochondrial β-oxidation | DECR1; HADHB; HADHA; ECI1; ECI2* ACADVL; ACADL; ECH1*; ECHS1 | — |
Peroxisome β-oxidation | ABCD3; HSD17B4 | — |
Lipid Homeostasis | CRAT; ACOT2*; ACOT7 | ACSF2 |
Glucose metabolism | ||
Glycolysis | ENO1 | ENO3*; PGAM2; HK2 |
Glycogen catabolism | — | PYGM |
Glycogen biosynthesis | — | GYS1 |
Conversion of pyruvate to acetyl-CoA | PDK4 | PDHA1; DLAT |
Amino acid metabolism | ||
BCAA oxidation | HIBADH | BCAT2; MCC2*; IVD |
Aspartate biosynthetic process | — | GOT2 |
Proline catabolic process to glutamate | — | ALDH4A1 |
Malate-aspartate shuttle | — | SLC25A12 |
Tricarboxylic acid cycle | MDH1 | IDH2; ACO2; ALDH5A1 |
Oxidative phosphorylation | ||
Electron transport chain | COX5B; ETFA | NDUFS1; NDUFS2; ETFDH |
ATP-synthase complex | ATP5F1D | ATP5F1A |
Energy transduction | — | CKM |
Antioxidant defence | PRDX3; PRDX5; SOD1; GSTA4 | PRDX6; GLO1; GSTM2; GSTO1; GSTZ1 |
Proteasome complex | — | PSMB5; PSMA7 |
Cytoskeleton | SPTBN2; JUP; SYNPO; FHL2; MYO1C | — |
Contraction | ||
Contractile proteins | MYL2 | MYH6 |
Regulatory proteins of Ca2+ handling | ATP2A2; RYR2 | — |
