Figure 3

Protein-protein interaction analysis and construction of the circRNA-miRNA-mRNA network. (A) Protein-protein interaction analysis of differentially expressed genes. Edge stands for the interaction between two genes. The more edge, the bluer the node. The importance of protein nodes in the network is described by degree where white denotes low and yellow denotes high. The molecular complex detection method (MCODE), as the significant modules, picked up from the PPI network by score of >6.0. Significant modules were identified from the PPI network using the molecular complex detection method with a score of >6.0. Unique shapes represented different clusters where triangles indicate cluster 1 and diamonds signifying cluster 2. The border color represents the fold change for DEGs where upregulated DEGs are marked red and downregulated DEGs marked blue. (B) PPI network for DEGs and DEMis. Edge stands for the interaction between two genes. The more edge, the redder the node. The importance of protein nodes in the network is described by degree where white denotes low and yellow indicates high. Unique shapes represent different clusters, and triangles indicates cluster 1, with diamonds signifying cluster 2. (C) Venn diagram for the overlap of numbers of the predicted circRNAs. (D) CircRNA-miRNA-hub gene network. Hsa_circ_0016274 as an item of circ-YOD1.