Figure 2
Significant post-interaction movement in CC′ loop: Panel a illustrates the superposition of 2B4 (ribbon, black):CD48 (ribbon, magenta) complex with apo structures of 2B4 (ribbon, yellow) and CD48 (ribbon, green), where CC′ loops of bound 2B4 and CD48 is shown in cyan and unbound 2B4 is shown in dark blue (only relevant part is shown for clarity). The CC′ loop of apo CD48 is not represented as it is not modelled in the PDB structure (PDB:2PTV). The FG loops of bound 2B4 and CD48 is shown in salmon and that of the apo structures is shown in red. Panel b illustrates the interactions of R43 (stick, cyan) of the CC′ loop of 2B4 with CD48 (stick, salmon). Panel c illustrates the interactions of the CC′ loop of CD48 (stick, cyan) with 2B4 (stick, salmon). Panel d illustrates the post-interaction movement of the CC′ loop (cyan) of PD-1 (cartoon, green) upon interaction with PD-L1 (cartoon, grey) when compared with the CC′ loop (dark blue) of apo PD-1 (cartoon, magenta). The sequence logo of residues of the CC′ loop of PD-1 is depicted in panel e.
