Figure 3 | Scientific Reports

Figure 3

From: The CC′ loop of IgV domains of the immune checkpoint receptors, plays a key role in receptor:ligand affinity modulation

Figure 3

Loop to β-strand transition of CC′ loop: Panel a illustrates the superposition of mPD-1 (cartoon, gold):mPD-L2 (cartoon, green) complex with apo structures of mPD-1 (light grey) and mPD-L2 (grey), only the relevant part is shown for clarity. The CC′ loops of bound and unbound mPD-L2 is cyan and dark blue respectively and the colouring scheme of FG loops are maintained in the same manner as Fig. 2. Panel b depicts the loop to β strand transition of CC′ loop of mPD-L2 upon binding to mPD-1. Panel c highlights the post-interaction movement of the CC′ loop of mPD-L2 and FG loops of mPD-1 and mPD-L2 which causes a three-way clamping.

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