Table 4 Pathways associated with the DEG after NPs, MPs and E171 exposure.
Time of exposure | Biological function | Name pathway | p-value |
|---|---|---|---|
E171 | Signal Transduction | GPCR downstream signalling | 1.09E-08 |
Signalling by GPCR | 3.75E-07 | ||
Olfactory Signalling Pathway | 2.05E-06 | ||
Olfactory transduction - Homo sapiens (human) | 3.36E-05 | ||
Olfactory receptor activity | 6.69E-05 | ||
GPCR ligand binding | 0.000236 | ||
Signal Transduction | 0.000461 | ||
G alpha (q) signalling events | 0.00222 | ||
Bone Morphogenic Protein (BMP) Signalling and Regulation | 0.00845 | ||
Transport of small molecules | Zinc efflux and compartmentalization by the SLC30 family | 0.00406 | |
Neuronal system | Dopaminergic Neurogenesis | 0.0004 | |
Developmental Biology | Interaction between L1 and Ankyrins | 0.0041 | |
Haemostasis | Endothelins | 0.00989 | |
Metabolism of proteins | Insulin processing | 0.00406 | |
MPs | Signal Transduction | Olfactory Signalling Pathway | 0.0579 |
Olfactory transduction - Homo sapiens (human) | 0.0579 | ||
Developmental Biology | CDO in myogenesis | 0.0654 | |
Myogenesis | 0.0654 | ||
Netrin-1 signalling | 0.0775 | ||
NPs | Metabolism | Glycine, serine, alanine and threonine metabolism | 0.000543 |
Creatine metabolism | 0.000789 | ||
Urea cycle and metabolism of amino groups | 0.00514 | ||
Glucocorticoid Receptor Pathway | 0.00541 | ||
Prostaglandin Synthesis and Regulation | 0.00861 | ||
Neuronal system | HCN channels | 8.60E-05 | |
TarBasePathway | 0.00126 | ||
Potassium Channels | 0.00689 | ||
Transport of small molecules | Amino acid transport across the plasma membrane | 0.00926 |
