Table 2 Subgroup analysis.

Subgroup	No of study	No of patients		Random-effect model		I ² (%)	Test of heterogeneity P
Subgroup	No of study	Early RRT	Late RRT	Risk Ratio	95% CI	I ² (%)	Test of heterogeneity P
Study population
Surgical	4	259	268	0.52	0.27–0.99	77	0.005
Mixed	7	872	843	10.4	0.93–1.17	0	0.71
Study design
Single center	4	249	262	0.51	0.20–129	81	0.001
Multicenter	7	882	849	1.02	0.91–1.14	0	0.96
Modality of RRT
IHD only	2	123	129	0.62	0.06–6.53	80	0.02
CRRT only	6	403	380	0.85	0.59–1.21	73	0.002
Mixed	3	605	602	1.01	0.88–1.15	0	0.70
Portion of patients with sepsis
100%	2	283	281	1.10	0.91–1.32	0	0.57
>50–<100%	3	417	420	0.98	0.84–1.14	0	0.88
Study site
Europe	6	888	856	0.94	0.76–116	63	0.02
Asia	4	195	203	0.66	0.28–1.56	78	0.003
North America	1	48	52	1.03	0.62–1.71	NA	NA

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