Figure 2
From: Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
Active conformation of the BMPR2 catalytic domain. (A) BMPR2 adopts an active conformation as shown by a salt bridge between the catalytic residues K230 and E243. Electrostatic hydrogen bond and salt bridge interactions are denoted by a blue dashed line together with their distances (Å). A large insertion in the activation loop is disordered. A sequence alignment reveals insertions here in the activation loops of BMPR2 and AMHR2 compared to other type II receptors.
