Figure 5

Dependence of the outcomes on the number of osteoarthritis localizations, quantitative analysis of multiple sources. (A) Dependence of all-cause mortality (AMRT) on age and the number of osteoarthritis localizations, 5540 patients in Kaiser Permanente sudy of the oldest old. Significance of differences between the cohorts is displayed. N = 3900 for the non-arthritis control (0 localizations), N = 1100 for osteoarthritis in 1 localization, N = 540 for osteoarthritis in 2 and more localizations. The cohorts are balanced by age and gender. (B) Dependence of dementia fraction on the number of osteoarthritis localizations, 5540 patients in Kaiser Permanente study of the oldest old. Siginificance of differences is displayed. The size of cohorts is the same as in (A). The cohorts are balanced by age and gender. (C) Dependence of outcomes in NACC database on the number of osteoarthritis localizations. White bars – control, 0 localizations (N = 6570), striped bars – 1 localization (N = 4015), grey bars – 2 localizations (N = 2830), black bars – 3 or more localizations (N = 2155). The outcomes are SFP – Short Follow-up fraction in the cohort, LFP – Long Follow-up fraction in the cohort, MINDEM – dementia fraction at the beginning of follow up, MAXDEM – dementia fraction at the end of follow up, AMRT – accrued all-cause mortality, COM/YEAR – annual rate of progression of total comorbidity count, DEM/YEAR – annual rate of dementia progression. The statistical significance of differences in AMRT is mapped. The cohorts are balanced by gender composition. (D) Dependence of outcomes in NACC database on the number of osteoarthritis localizaitons. The outcomes are the initial age of cohort at the beginning of follow up (white bars), the final age of cohort at the end of follow up (grey bars), the lifespans in the cohort (black bars). Significance of the differences is mapped. 0 – control, 1 – one localization, 2 – two localizations, 3 – three and more localizations. The cohorts are balanced by gender conposition. (E) Lifespan in different forms of osteoarthritis in NBER database. M19 – osteoarthritis of hand, N = 4100, M17 – osteoarthritis of knee, N = 62, M16 – osteoarthritis of hip, N = 47, M47 – osteoarthritis of spine, N = 123, M15 – polyosteoarthritis, N = 65, M06* - rheumatoid arthrtiis, N = 3353. The confidence intervals (CI95) are provided. A control with 566036 patients with 1–10 cardiovascular conditions was provided, measuring 76.77 ± 0.02 average lifespan.