Figure 3 | Scientific Reports

Figure 3

From: A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase

Figure 3

Reagents and conditions: (i) HCl, EtOH, reflux, o.n., 79–90%; (ii) NEt3, THF, -10 °C to r.t., 3 h, 75–99%; (iii) 1 M NaOH/EtOH, EtOH, r.t., 30 min., 33–55%; (iv) Pyridine, r.t., o.n., 68–87%; (v) K3PO4, Pd(dppf)Cl2, H2O/DMF, MW, 130 °C, 75 min., r.t., o.n. OR Na2CO3, Pd(OAc)2, PPh3, H2O/DME, MW, 85 °C,10 min., 34–51%; (vi) AcOH, 120 °C, o.n., OR EtOH, reflux, o.n., OR MeOH, reflux, 2 h, 48–65%; (vii) LiOH, THF/MeOH/H2O, r.t., o.n., OR 2 M NaOH, 1,4-Dioxane, o.n., 49–55%; (viii) HCl, NaNO2, SnCl2, 0 °C, 3 h, 99%.

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