Table 1 IC50 values of hit compounds against HuNoV (GII.4) RdRp activities.

From: A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase

Compound

Structure

IC50 values [μM]A

2

R = 4-COOH, Ar = Ph

17.2 ± 2.4

3

R = 3-COOH, Ar = Ph

22.5 ± 6.5

34

R = 4-COOEt, Ar = Ph

13.5 ± 5.8

35

R = 3-COOEt, Ar = Ph

18.9 ± 3.1

4

R = H, Ar = 2-Pyrimidine

n.d.

5

R = H, Ar = 2-Oxazole

12.8 ± 2.6

6

R = H, Ar = 2-Benzimidazole

26.7 ± 2.0

7

n.d.

1

R = H, Ar = Ph

5.6B

PPNDS

1.5 ± 0.25

  1. AMean values ± standard deviations of triplicate datasets are shown from at least three independent experiments.
  2. BActivity data as previously reported29.
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