Table 3 Effects of varying the DSB yield.

From: Stochastic multicellular modeling of x-ray irradiation, DNA damage induction, DNA free-end misrejoining and cell death

DSB/cDSB yieldsa (/Gy/cell) under full oxia

OERDSB

OERcDSB

αmr (Gy−1)/βmr (Gy−2) under full oxia (anoxia)b,c

αkilling(mr) (Gy−1)/βkilling(mr) (Gy−2) under full oxia (anoxia)d,e

SF2(mr) under full oxia (anoxia)f,e

OERkilling(mr)g,e

20.1/1.9

4.6

3.9

0h/0.19 (0h/0.01)

0i/0.09 (0i/0.01)

0.70 (0.97)

3.6

30.1/2.9

4.6

3.9

0.02/0.37 (0h/0.03)

0.02/0.17 (0i/0.02)

0.49 (0.94)

3.4

40.2/3.9

4.6

4.0

0.07/0.56 (0.00/0.04)

0.04/0.25 (0.00/0.02)

0.34 (0.92)

3.6

  1. aUsing the slopes of the fits \({N}_{DSB}={m}_{DSB}D\) and \({N}_{cDSB}={m}_{cDSB}D\). bFit to \({N}_{mr}={\alpha }_{mr}D+{\beta }_{mr}{D}^{2}\). cUsing r0 = 0.7 μm. dFit to \({P}_{surv(mr)}={e}^{-{\alpha }_{{\rm{killing}}(mr)}D-{\beta }_{{\rm{killing}}(mr)}{D}^{2}}\). eUsing r0 = 0.7 μm and \({P}_{nlmr}=0.5\). fUsing the fit to \({P}_{surv(mr)}\) and extrapolating to 2 Gy. gUsing \({{\rm{OER}}}_{{\rm{killing}}(mr)}={D}_{10}({{\rm{pO}}}_{2}\,{\rm{of}}\,0\,{\rm{mmHg}})/\)\({D}_{10}({{\rm{pO}}}_{2}\,{\rm{of}}\,760\,{\rm{mmHg}})\), where D10 was obtained by extrapolating the fit to \({P}_{surv(mr)}\). hThe fit gave \(-0.01\lesssim {\alpha }_{mr} < 0\), so the fit was reperformed to \({N}_{mr}={\beta }_{mr}{D}^{2}\). iThe fit gave \(-0.01 < {\alpha }_{{\rm{killing}}(mr)} < 0\), so the fit was reperformed to \({P}_{surv(mr)}={e}^{-{\beta }_{{\rm{killing}}(mr)}{D}^{2}}\).
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