Table 1 Inhibitory activity of the 4,5-diaryl 2H-1,2,3-triazoles, 4-carboxylate-5-aryl-2H-1,2,3-triazoles and 4-carboxamide-5-aryl-2H-1,2,3-triazoles against purified human IDO1 enzyme.

Substituents		Compound 1		Compound 2		Compound 3
R₁	R₂		hIDO1 IC₅₀ (µM)^a		hIDO1 IC₅₀ (µM)^a		hIDO1 IC₅₀ (µM)^a
H	H	1a	90.033 ± 2.942	2a	14.390 ± 3.357	3a	8.541 ± 0.084
H	Me	1b	54.871 ± 0.757	2b	1.699 ± 0.061	3b	7.082 ± 0.691
F	H	1c	4.991 ± 0.057	2c	31.440 ± 4.207	3c	6.611 ± 0.355
Cl	H	1d	2.513 ± 0.060	2d	2.550 ± 0.033	3d	2.687 ± 0.055
Br	H	1e	21.870 ± 1.270	2e	2.981 ± 0.012	3e	26.680 ± 2.199
H	F	1f	25.240 ± 1.703	2f	8.090 ± 0.210	3f	2.941 ± 0.034
H	Cl	1g	3.208 ± 0.100	2g	0.392 ± 0.084	3g	0.624 ± 0.023
H	Br	1h	40.720 ± 2.696	2h	18.450 ± 1.676	3h	5.156 ± 0.011
F	F	1i	7.721 ± 0.761	2i	0.545 ± 0.029	3i	0.111 ± 0.005
Cl	Cl	1j	12.910 ± 0.191	2j	0.163 ± 0.025	3j	0.069 ± 0.004
Cl	F	1k	6.913 ± 0.099	2k	1.691 ± 0.102	3k	1.831 ± 0.126
Br	F	1 l	1.935 ± 0.083	2 l	3.035 ± 0.091	3 l	1.993 ± 0.005

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