Table 3 Subgroup analysis of the crude and adjusted hazard ratios (95% confidence interval) of asthma for migraines according to age and sex in study I.

From: Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

Characteristics

Hazard ratios (HR) for migraine

Crude

P-value

Adjusted†‡

P-value

Age <40 years, men (n = 22,102)

  Asthma

2.24 (1.82–2.76)

<0.001*

2.05 (1.67–2.54)

<0.001*

  Control I

1.00

 

1.00

 

Age <40 years, women (n = 43,862)

  Asthma

1.79 (1.63–1.96)

<0.001*

1.64 (1.49–1.79)

<0.001*

  Control I

1.00

 

1.00

 

Age 40–59 years, men (n = 31,696)

  Asthma

1.90 (1.63–2.21)

<0.001*

1.73 (1.49–2.01)

<0.001*

  Control I

1.00

 

1.00

 

Age 40–59 years, women (n = 52,804)

  Asthma

1.44 (1.35–1.55)

<0.001*

1.33 (1.24–1.43)

<0.001*

  Control I

1.00

 

1.00

 

Age ≥60 years, men (n = 30,546)

  Asthma

1.58 (1.38–1.80)

<0.001*

1.45 (1.27–1.66)

<0.001*

  Control I

1.00

 

1.00

 

Age ≥60 years, women (n = 45,108)

  Asthma

1.51 (1.39–1.63)

<0.001*

1.39 (1.28–1.50)

<0.001*

  Control I

1.00

 

1.00

 
  1. *Cox-proportional hazard regression model. Significance at P < 0.05.
  2. Model stratified by age, sex, income, and region of residence.
  3. Model adjusted for depression history and Charlson Comorbidity Index calculated without pulmonary disease.