Table 2 Cox regression model – association between high methylation versus low methylation of the nt-937 AQP5 promoter region regarding 30-day mortality.
From: DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis
Variable | Estimates | |||
|---|---|---|---|---|
HR | 95% CI | p-value | ||
Univariate | nt-937: high$ methylation (vs. low§) | 3.33 | (1.69–6.55) | <0.001 |
Multivariate | nt-937: high$ methylation (vs. low§) | 3.31 | (1.54–6.23) | 0.002 |
Age (per year) | 1.00 | (0.98–1.02) | 0.816 | |
Male sex (vs. female sex) | 1.00 | (0.56–1.82) | 0.990 | |
SOFA Score (per point) | 1.05 | (1.01–1.11) | 0.043 | |
Mechanical ventilation | 2.15 | (1.10–4.21) | 0.025 | |
