Table 2 Average volume, cell population, cell density, microglia population, and microglia density in all regions counted across the prefrontal cortex and striatum.

From: Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model

 

Naïve

Maltodextrin

Alcohol

Orbitofrontal Cortex

Volume (mm³)

2.04 (0.14)

2.07 (0.13)

1.89 (0.06)

Cell Population (×104)

62.36 (5.820)#

57.76 (5.63)*

38.31 (2.53)#*

Cell density (cells/mm³) (×104)

30.76 (3.16)#

27.65 (1.03)

20.42 (1.44)#

Microglia population (×10³)

13.45 (0.80)

13.01 (1.09)

12.02 (0.80)

Microglia density (cells/mm³) (×10³)

6.61 (0.09)

6.30 (0.33)

6.36 (0.32)

Medial Prefrontal Cortex

Volume (mm³)

5.04 (0.25)

5.07 (0.14)

5.03 (0.13)

Cell Population (×104)

120.65 (6.35)#

119.06 (8.70)*

87.38 (6.23)#*

Cell density (cells/mm³) (×104)

24.12 (1.56)#

23.34 (1.06)*

17.36 (1.15)#*

Microglia population (×10³)

29.55 (1.63)

27.82(1.02)

29.24 (1.87)

Microglia density (cells/mm³) (×10³)

5.97 (0.31)

5.51312 (0.29143)

5.79 (0.25)

Motor Cortex

Volume (mm³)

3.96 (0.14)

3.71 (0.20)

3.61 (0.22)

Cell Population (×104)

95.54 (5.64)#

90.56 (2.64)*

72.42 (5.04)#*

Cell density (cells/mm³) (×104)

24.17 (1.06)

24.69 (1.07)*

20.22 (1.38)*

Microglia population (×10³)

23.63 (0.73)

21.73 (1.70)

21.85 (1.61)

Microglia density (cells/mm³) (×10³)

5.98 (0.14)

5.85 (0.29)

6.06 (0.33)

Sensory Cortex

Volume (mm³)

4.96 (0.25)

4.84 (0.30)

4.94 (0.10)

Cell Population (×104)

132.14 (9.50)

122.48 (9.23)

100.54 (6.85)

Cell density (cells/mm³) (×104)

26.87 (2.17)#

25.31 (0.99)

20.44 (1.66) #

Microglia population (×10³)

28.89 (0.90)

28.31 (1.24)

29.67 (1.02)

Microglia density (cells/mm³) (×10³)

6.02 (0.11)

5.93 (0.35)

6.02 (0.24)

Dorsal Striatum

Volume (mm³)

12.68 (0.83)

12.63 (0.34)

13.06 (0.62)

Cell Population (×104)

104.26 (11.50)

115.06 (7.98)

107.73 (6.50)

Cell density (cells/mm³) (×104)

8.18 (0.65)

9.09 (0.51)

8.29 (0.43)

Microglia population (×10³)

78.88 (9.37)

69.44 (5.41)

73.34 (8.61)

Microglia density (cells/mm³) (×10³)

6.26 (0.65)

5.53 (0.48)

5.67 (0.64)

Ventral Striatum

Volume (mm³)

7.32 (0.31)

6.94 (0.31)

7.15 (0.23)

Cell Population (×104)

72.04 (5.27)

69.78 (2.29)

72.82 (3.82)

Cell density (cells/mm³) (×104)

9.83 (0.52)

10.12 (0.43)

10.18 (0.43)

Microglia population (×10³)

44.99 (4.81)

44.44 (3.33)

46.58 (2.72)

Microglia density (cells/mm³) (×10³)

6.16 (0.63)

6.40 (0.38)

6.54 (0.41)

  1. n = 6 per group. #indicates Alcohol < Naïve, p < 0.05), * indicates Alcohol < Maltodextrin, p < 0.05). Data presented individual data points as well as mean ± SEM. All populations were obtained with a CE below 0.150 (see Supplementary Material).