Figure 4 | Scientific Reports

Figure 4

From: Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

Figure 4

Apoptosis, Ki67 and phospho-histone H3 expression in OV1002 and HOX 424 xenografts after treatment with PF-04691502 and gedatolisib. (A) Mean number of apoptotic bodies in a high-field (x 40) view for OV1002 xenografts and HOX 424 xenografts. Mean values shown are average values for each group of xenografts. Ten fields were evaluated for each individual xenograft and the mean value was evaluated. (B) Ki67 expression. Mean % Ki67 expression is shown. C. Phospho-histone H3 expression. Mean % value (+/− S.D.) is shown for each group. *P < 0.05 shown for ANOVA followed by Tukey post-test.

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