Table 3 Parameters associated with gamma-glutamyltransferase (GT).

From: Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction

 

Univariable

Multivariable

Odds Ratio (95% CI)

p-value

Odds Ratio (95% CI)

p-value

Clinical parameters

Age

0.988 (0.960–1.016)

0.397

  

Female

1.669 (0.992–2.809)

0.054

  

Body Mass Index

1.021 (0.986–1.059)

0.243

  

Fat Tissue Index

0.989 (0.942–1.038)

0.641

  

Total Fat Mass

0.990 (0.967–1.015)

0.438

  

Relative Fat Mass

0.975 (0.943–1.008)

0.133

  

Systolic blood pressure

0.994 (0.982–1.006)

0.308

  

Diastolic blood pressure

1.004 (0.985–1.024)

0.661

  

Prior HF hospitalization

1.702 (0.950–3.049)

0.074

  

Atrial fibrillation

3.140 (1.902–5.181)

<0.001

  

Hypertension

1.846 (0.528–6.4559

0.337

  

Hyperlipidemia

0.807 (0.500–1.301)

0.379

  

Diabetes mellitus

1.263 (0.774–2.062)

0.350

  

History of CAD

0.729 (0.419–1.268)

0.263

  

COPD

1.420 (0.857–2.351)

0.173

  

Echocardiographic parameters

LA diameter

1.061 (1.024–1.099)

0.001

  

LA indexed for BSA

1.023 (0.999–1.047)

0.059

  

LVEDD

0.994 (0.948–1.042)

0.801

  

RA diameter

1.064 (1.030–1.100)

<0.001

  

RVEDD

1.060 (1.021–1.101)

0.002

  

IVS

1.009 (0.915–1.112)

0.863

  

E/E’ ratio

1.033 (0.959–1.112)

0.395

  

E/A ratio

2.173 (1.108–4.260)

0.024

2.173 (1.108–4.260)

0.024

Significant TR

3.153 (1.846–5.385)

<0.001

  

Hemodynamic parameters

Systolic PAP

1.027 (1.011–1.044)

0.001

  

Diastolic PAP

1.069 (1.029–1.112)

0.001

  

Mean PAP

1.062 (1.031–1.094)

<0.001

  

Mean RAP

1.140 (1.078–1.206)

<0.001

1.139 (1.076–1.205)

<0.001

PAWP

1.110 (1.055–1.168)

<0.001

  

SaO2

1.041 (0.982–1.102)

0.176

  

TPG

1.044 (1.005–1.084)

0.025

  

PVR

1.002 (1.000–1.004)

0.048

  

SV

0.996 (0.983–1.008)

0.496

  

CO thermodilution

1.037 (0.856–1.258)

0.709

  

CO Fick

0.898 (0.714–1.130)

0.358

  

Magnetic resonance imaging parameters

LA

1.036 (1.000–1.073)

0.050

  

LVEDV

1.006 (0.998–1.014)

0.132

  

RA

1.052 (1.013–1.092)

0.009

1.070 (1.026–1.115)

0.001

RVEDV

1.012 (1.005–1.019)

0.001

  

IVS

1.022 (0.879–1.188)

0.779

  

LVEF

1.000 (0.983–1.017)

0.982

  

RVEF

0.963 (0.935–0.992)

0.014

  
  1. A - mitral peak velocity of late filling, CAD - coronary artery disease, CO - cardiac output, COPD - chronic obstructive pulmonary disease, E - early mitral inflow velocity, E’ - early diastolic mitral annular velocity, ECV - extra cellular volume, HF – heart failure, IVS - inter-ventricular septum, LA - left atrial, LVEDV - left ventricular end-diastolic volume, LVEF - left ventricular ejection fraction, PAP - pulmonary artery pressure, PAWP - pulmonary artery wedge pressure, PVR - pulmonary vascular resistance, RA - right atrial, RAP - right atrial pressure, RVEDV - right ventricular end-diastolic volume, RVEF - right ventricular ejection fraction, SaO2 - arterial saturation of oxygen, SV - stroke volume, TPG - transpulmonary gradient, TR – tricuspid regurgitation.
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