Figure 4 | Scientific Reports

Figure 4

From: Enteric neuronal cell therapy reverses architectural changes in a novel diphtheria toxin-mediated model of colonic aganglionosis

Figure 4

DT-induced focal aganglionosis does not affect total GI transit and colonic motility. A radiologic-based transit assay (a,a’) was used to measure solid and liquid transit following DT injection. No difference was observed in solid transit at 2 and 4 weeks after DT injection (b). Liquid transit showed a delay at 2 weeks, but not at 4 weeks (c). Ex vivo analysis by spatiotemporal mapping of the DT-injected colon from Wnt1-iDTR mice showed no changes in CMMC frequency (d), length (e), or velocity (f), as compared to controls.

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