Figure 2

Genomic alterations observed in SCC-R cells: (a) Summary of SNVs observed in SCC-R cells. (b) CNAs identified using OncoCNV in SCC-R cells. Each dot corresponds to an amplicon. (Color code – green dots: outliers; grey dots: unchanged amplicons; plum color surroundings: 1-level gain; all purple dots in red circles represent copy number amplifications >1-level gain while yellow circles represent copy number loss in SCC-R cells). Single nucleotide variant in SCC-R cells resulting in (c) p.G13R in HRAS in SCC-R cells. (d) p.K57E in gene MAP2K1. (e) Copy number profile of AKT2 and AXL in SCC-R cells. Each dot corresponds to an amplicon. (Color code – red dots: gene amplicon, green dots: other amplicons; grey dots: outliers).