Figure 3
Proteomic and phosphoproteomic alterations in SCC-R cells: (a) Distribution of log2 transformed protein fold changes comparing the expression levels in SCC-R cells over SCC-S cells. (Red dots = overexpressed by ≥2 fold, Blue dots = downregulated by ≥2 fold) (b) Scatter plot of log2 transformed phosphosite ratios with total protein expression ratios (black dots depict dysregulation of total protein and phosphosite by ≥2 fold, cyan dots depict dysregulation of phosphosite by ≥2 fold at phosphopeptide level only) (c) Circos plot representing genomic and proteomic alterations in SCC-R cells compared to SCC-S cells. Chromosome ideograms are shown around the outer ring (Track A) and are oriented pter–qter in a clockwise direction with centromeres indicated in red. Other tracks contain alterations (from outside to inside): Track B- silent SNVs (cyan dots), Track C- non-synonymous SNVs (magenta dots), Track D- copy number alterations (red dots = CNA gain, grey dots = CNA neutral, and dark green dots = CNA loss), Track E- dysregulated proteins (orange dots = overexpressed, light blue dots = downregulated, fold change ≥2), Track F- altered phosphosites (purple dots = hyperphosphorylated, green dots = hypophosphorylated, fold change ≥2).
