Figure 2 | Scientific Reports

Figure 2

From: Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation

Figure 2

Mutant IDH1 increases glycolytic flux in IBOs. (A) Metabolome analysis of IBOs stably expressing empty vector (EV), wild-type IDH1 (Wild) or mutant IDH1 (R132C) by CE-MS (n = 4, *P < 0.05, NS not significant). (B) Glucose uptake in the indicated IBOs (n = 3, *P < 0.05). Abbreviation; α-KG, α-ketoglutarate; AMP, adenosine monophosphate; ATP, adenosine triphosphate; CMP, cytidine monophosphate; CTP, cytidine triphosphate; DHAP, dihydroxyacetone phosphate; F1,6 P, fructose-1,6-bisphosphate; F6P, fructose 6-phosphate; GMP, guanosine monophosphate; G3P, glyceraldehyde 3-phosphate; G6P, glucose-6-phosphate; GTP, guanosine triphosphate; 6-PG, 6-phosphogluconate; PEP, phosphoenolpyruvate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; R5P, ribose 5-phosphate; Ru5P, ribulose 5-phosphate; S7P, sedoheptulose-7-phosphate; UDP, uridine diphosphate UDP-GlcNAc, uridine diphosphate N-acetylglucosamine; UMP, uridine monophosphate; UTP, uridine triphosphate.

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