Table 1 Meta-analysis of previously reported in vivo BDNF measurements taken with and without IN delivery of BDNF.
Species | Total BDNF Delivered | In vivo BDNF Measurements | Time point | Method | Report |
|---|---|---|---|---|---|
Mice | No BDNF | 559.9 ng/g (hippocampus) | baseline | ELISA | |
Rats | No BDNF | 636.1 ng/g (hippocampus) | baseline | ELISA | |
Mice | No BDNF | 27.77 ng/g (striatum) | baseline | ELISA | |
— | — | 29.48 ng/g (hippocampus) | baseline | ELISA | |
Rats | No BDNF | 0.16 ng/g (whole brain) | baseline | ELISA | |
Rats | 5 ug of rhBDNF | 0.056 ng/L (hippocampus) | 4 hours | Microdialysis | |
Rats | 70 ug of [125I]-BDNF rhBDNF | 1.7 ng/L (hippocampus) | 1 hour | Gamma Counter | |
Mice | 5 ug of [125I]-BDNF rhBDNF | 0.05% inj/g (midbrain) | 30 min | Gamma Counter | |
— | — | 0.2% inj/g (striatum) | 30 min | Gamm Counter | |
— | — | 0.1% inj/g (whole brain) | 5 min | Gamma Counter | |
Rats | 40 ug of BDNF | 4.33 ng/g (whole brain) | 1 hour | ELISA | |
Mice | 400 ug of rhBDNF | 49.91 ng/mL || 29.05 ug/g || 7.2%/g (striatum) | 1 hour | ELISA | This study |
— | — | 45.57 ng/mL || 35.07 ug/g || 8.7%/g (midbrain) | 1 hour | ELISA | This study |
