Figure 1

Manifestation of severe malaria during blood-stage P. coatneyi infection in rhesus and cynomolgus macaques. (A) The study schedule indicates sample collection timepoints and the number of animals per species during the course the infection. (B) Clinical indicators of severe malaria and (C–H) laboratory indicators of severe malaria in rhesus (n = 4) and cynomolgus (n = 4) macaques infected with blood-stage P. coatneyi. For the graphs in the left panel (C–E) values above the dashed line represent severe malaria and for the graphs in the right panel values below the dashed line represent severe malaria. Error bars show the SEM for each group. Using linear mixed-effects models the (C) parasitaemias of infected rhesus and cynomolgus macaques were compared between days 4 and 11, when all animals remained alive (p = 0.56), and days 12 and 15, when the number of animals per group was decreasing (**p < 0.001).